| Insider | Role | Shares | Value | Buys | Sells |
|---|---|---|---|---|---|
| Date | Ticker | Insider | Role | Type | Shares | Price | Value | Chg% | SEC |
|---|---|---|---|---|---|---|---|---|---|
| Insider | Role | Shares | Value | Buys | Sells |
|---|---|---|---|---|---|
| Date | Ticker | Insider | Role | Type | Shares | Price | Value | Chg% | SEC |
|---|---|---|---|---|---|---|---|---|---|
Chief Medical Officer | Chief Discovery/ Trans Medicine | Senior Vice President
1 company
James C Hamilton is Chief Medical Officer at ARWR. James C Hamilton's net worth is not public. Form 4 filings only show shares in the companies where this person is an insider; those holdings are worth an estimated $13.5M at current prices.
Our model assigns James C Hamilton a middling insider score of 58/100, based on 18 past trades. Over a 12-month horizon, 60.0% of those trades were profitable, with an average 12-month return of -17.9%.
The ARWR filings lean toward selling, a net 306,792 shares.
James C Hamilton has 20 Form 4 filings on record from January 2021 to April 2026, all as Chief Medical Officer at Arrowhead Pharmaceuticals (ARWR), 2021–2026.
The 62 reported transactions were 56 open-market sales and 6 stock awards.
Counted by filing, the open-market trades come to no purchases and 17 sales worth about $14.4M.
The largest open-market sale was 38,750 shares of ARWR at an average $72.51 on January 6, 2021, about $2.8M.
10 of the 12 sales since April 2023 were made under a Rule 10b5-1 trading plan; the other 2 were not.
| Date | Ticker | Role | Type | Shares | Price | Value | Chg% | 3M | 12M | SEC |
|---|---|---|---|---|---|---|---|---|---|---|
| Apr 23, 2026 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Medical Officer | Sell10b5-1 | 10,000 | $75.00 | $750,000.00 | -4.2% | +19.2% | - | |
| Mar 5, 2026 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Medical Officer | Sell10b5-1 | 10,000 | $64.19 | $641,900.00 | -4.0% | +14.1% | - | |
| Jan 5, 2026 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Medical Officer | Sell10b5-1 | 40,164 | $63.11 | $2,534,661.46 | -18.9% | -4.3% | - | |
| Oct 1, 2025 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Medical Officer | Sell10b5-1 | 20,000 | $35.00 | $700,000.00 | -8.6% | +92.1% | +85.1% | |
| Sep 12, 2025 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Medical Officer | Sell10b5-1 | 15,000 | $30.00 | $450,000.00 | -6.1% | +138.3% | +178.8% | |
| Sep 2, 2025 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Medical Officer | Sell10b5-1 | 15,000 | $25.00 | $375,000.00 | -5.7% | +119.0% | +232.4% | |
| Aug 15, 2025 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Medical Officer | Sell10b5-1 | 10,000 | $20.00 | $200,000.00 | -3.7% | +100.6% | +322.4% | |
| Jan 6, 2025 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Discovery/ Trans Medicine | Sell10b5-1 | 32,729 | $19.82 | $648,824.25 | -10.7% | -47.4% | +263.1% | |
| Apr 1, 2024 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Discovery/ Trans Medicine | Sell | 6,000 | $28.03 | $168,180.00 | -2.8% | -7.8% | -56.8% | |
| Jan 12, 2024 | ARWR Arrowhead Pharmaceuticals, Inc. | Chief Discovery/ Trans Medicine | Sell10b5-1 | 7,940 | $36.89 | $292,903.60 | -3.6% | -29.5% | -49.2% |