| Insider | Role | Shares | Value | Buys | Sells |
|---|---|---|---|---|---|
| Date | Ticker | Insider | Role | Type | Shares | Price | Value | Chg% | SEC |
|---|---|---|---|---|---|---|---|---|---|
| Insider | Role | Shares | Value | Buys | Sells |
|---|---|---|---|---|---|
| Date | Ticker | Insider | Role | Type | Shares | Price | Value | Chg% | SEC |
|---|---|---|---|---|---|---|---|---|---|
Director | Director, Director | Director, Chairman of Board
2 companies
Joseph Loscalzo is Director at CYPH and has filed Form 4s across 2 companies. Joseph Loscalzo's net worth is not public. Form 4 filings only show shares in the companies where this person is an insider; those holdings are worth an estimated $1.9M at current prices.
Historically, Joseph Loscalzo's trades have earned a middling insider score of 55/100 across 6 rated trades. Over a 12-month horizon, 66.7% of those trades were profitable, with an average 12-month return of -16.1%.
The biggest single holding is IONS (~$1.5M) as Director. The IONS filings lean toward selling, a net 123,829 shares.
Joseph Loscalzo has 35 Form 4 filings on record from January 2017 to July 2026, across 2 companies: Director at Ionis Pharmaceuticals (IONS), 2019–2026; Director at Cypherpunk Technologies (CYPH), 2017–2026.
The 70 reported transactions were 33 option or other derivative awards, 30 option exercises and 7 open-market sales.
Counted by filing, the open-market trades come to no purchases and 5 sales worth about $8.6M.
The largest open-market sale was 77,289 shares of IONS at an average $75.06 on May 4, 2026, about $5.8M.
4 of the 5 sales since April 2023 were made under a Rule 10b5-1 trading plan; the other was not.
| Date | Ticker | Role | Type | Shares | Price | Value | Chg% | 3M | 12M | SEC |
|---|---|---|---|---|---|---|---|---|---|---|
| May 4, 2026 | IONS Ionis Pharmaceuticals, Inc. | Director | Sale+OE10b5-1 | 77,289 | $75.06 | $5,801,226.23 | -68.0% | -27.8% | - | |
| Mar 4, 2026 | IONS Ionis Pharmaceuticals, Inc. | Director | Sale+OE10b5-1 | 1,032 | $80.26 | $82,832.81 | -2.8% | -8.2% | - | |
| Oct 31, 2025 | IONS Ionis Pharmaceuticals Inc | Director | Sale+OE10b5-1 | 16,000 | $75.10 | $1,201,668.80 | -30.6% | +12.9% | -40.3% | |
| Sep 3, 2025 | IONS Ionis Pharmaceuticals Inc | Director | Sale+OE | 16,000 | $60.15 | $962,371.20 | -30.6% | +34.4% | -3.9% | |
| Nov 12, 2024 | IONS Ionis Pharmaceuticals Inc | Director | Sell10b5-1 | 13,508 | $37.86 | $511,426.39 | -29.5% | -16.7% | +92.4% |